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Discovery
Research: |
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The Drug discovery laboratory is
equipped with multi facet capabilities and
potential research experts. The erudite and
distinct experience of our scientists helps them
to act efficiently for accomplishing the
sequential activities of the drug discovery
activity mentioned below. |
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  Hit
identification: The lab is facilitated with
latest software to identify the molecules that hit
the receptor site and provides better
pharmacological action.
Lead
identification: Molecules from hit
identification are short listed for lead identification by
means of synthesis and structure activity
relationship.
Lead
optimization: The lead molecules are further
optimized to produce molecules with
biological activity.
The laboratory is supported by experts belonging
to the fields of Molecular modeling,
Pharmacology & Toxicology and Pharmacokinetics.
NCE Pipeline
Molecules have
developed new chemical entities for the
treatment of the fatal disease Tuberculosis.
These drugs are in their preclinical studies at NIH (National Institute of Health), Maryland,
USA. The codes of the drugs in pipe line are as
follows.
• AS9
• AS10
• AS11
• AM13 |
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Oncology |
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 Cancer is a killer disease takes more than 7.4
million lives all over the world every year. The
cancer rates are increasing at an alarming rate.
The current chemotherapeutic agents damages
normal cells along with cancer cells and cause
lot of unpleasant side effects. Our focus is
mainly to identify and develop Multi Targeting
Mono Chemotherapeutic Agents (MTMA) that can
work with multiple mechanisms at cellular level
and target only cancer cells. |
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Tuberculosis |
 Tuberculosis (TB) is a potentially fatal
contagious disease that can affect almost any
part of the body but is mainly an infection of
the lungs. It is caused by a bacterial micro
organism, the tubercle bacillus or Mycobacterium
tuberculosis. Every second a new patient is
infected with tuberculosis bacilli and nearly 2
billion people ie., one third of the world’s
population are infected by mycobacterium
tuberculosis. It is the second most common cause
for mortality rate all over the world. Nearly
two million people die out of tuberculosis every
year. The current therapy is associated with
many side effects, poor patient compliance and
has a very lesser cure rates. Also there is a
possibility of developing multi drug resistant (MDR)
species of the bacterium in many cases. So there
is urgent need to develop drug to overcome the
existing drawbacks. |
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AIDS |
 About 33.2 million people are living with HIV
today. The disease is highly complicated and
AIDS patients are mostly prone to get affected
by TB. The existing treatment cause more harm
than helping the patients. Also there is an
emergence to design and synthesize Anti retro
viral agents as the HIV mutates and reproduce
itself into drug resistant strains and spread
inside the body at a faster rate. We are
developing potent drugs to stop HIV and
progression of the disease. |
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Cardiovascular diseases |
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CVDs account for more than 30%
of all global deaths. The major
CVDs include the following. |
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Coronary (or ischaemic) heart
disease (heart attack)
Cerebrovascular disease (stroke)
Hypertension (high blood pressure)
Heart failure
Rheumatic heart disease |
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New cell-based therapeutic strategies are being
developed in response to the shortcomings of
available treatments for heart disease. |
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CNS disorders |
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 Our main area of interest in this field is
Alzheimer’s disease. Alzheimer's disease (AD) is
a degenerative brain syndrome characterized by a
progressive decline in memory, thinking,
comprehension, calculation, language, learning
capacity and judgement sufficient to impair
personal activities of daily living. The rate of
occurrence of AD doubles every five years for
those between the 65 and 85 years of age. Our
research is based on discovering drugs for
reversing nerve cell damage. |
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Metabolic disorders |
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The main areas targeted in this category are
diabetes and obesity.
 Diabetes is a chronic
disease that occurs when the pancreas does not
produce enough insulin, or when the body cannot
effectively use the insulin it produces. Hyperglycaemia, or raised blood sugar, is a
common effect of uncontrolled diabetes and over
time leads to serious damage to many of the
body's systems, especially the nerves and blood
vessels. Diabetes causes about 5% of all deaths
globally each year. Our perspective is that the
drug treatment of diabetes is lacking in
convincing long-term efficacy and there are
number of important concerns about side effects
and long-term adverse effects.
Obesity is an emerging problem globally. The
disease shows an association with other dreadful
diseases such as cardiovascular diseases,
diabetes mellitus, sleep apnea, certain types of
cancer and osteoarthritis. Some anti-obesity
drugs have severe and often life-threatening
side effects such as risk of high blood
pressure, faster heart rate, palpitations,
closed-angle glaucoma, drug addiction,
restlessness, agitation, and insomnia. So there
is an emergence for improving the drugs that
serve to produce better cure rates with reduced
side effects. |
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hr@moleculeslab.comont>
